A total of six plant extracts were screened for antimicrobial activity against standard bacterial and fungal species. These were carried out by the cup plate agar diffusion on Mueller-Hinton agar (MHA) for bacteria and Sabouraud Dextrose Agar (SDA) for fungi. The Minimum Inhibitory Concentrations (MICs) of the most active extracts were determined by agar plate dilution method. Six extracts exhibited inhibitory activity against one or more of the six tested bacteria. Two extracts were inhibitory to the six tested organisms. Methanol extract of Acacia ehrenbergiana had a wide spectrum activity against all the bacteria tested with promising minimum inhibitory concentrations. However, the extracts were inactive against the fungal species tested.