Vol. 5, Issue 1 (2019)
Histogenesis of pancreas in human fetuses at different weeks of gestation with implications of cadaveric pancreatic transplants in insulin dependent diabetes mellitus patients
Author(s): Arpan Haldar, Sanjukta Sahoo, Soumya Chakraborty, Dipti Basu, Provas Banerjee
Abstract: The pancreas is formed by two buds originating from the endodermal lining of the duodenum, the dorsal pancreatic bud is in the dorsal mesentery and the ventral pancreatic bud is close to the bile duct. The ventral bud forms the uncinate process and inferior part of the head of the pancreas whereas the remaining part of the gland is derived from the dorsal bud. The main pancreatic duct (of Wirsung) is formed by the distal part of the dorsal pancreatic duct and the entire ventral pancreatic duct. The proximal part of the dorsal pancreatic duct either is obliterated or persists as a small channel, the accessory pancreatic duct (of Santorini). In the third month of fetal life, pancreatic islets (of Langerhans) develop from the parenchymatous pancreatic tissue and scatter throughout the pancreas. Insulin secretion begins at approximately the fifth month. Glucagon- and somatostatin-secreting cells also develop from parenchymal cells. Splanchnic mesoderm surrounding the pancreatic buds forms the pancreatic connective tissue. Aborted human foetuses without obvious congenital anomaly of gestational age between 12 weeks and 36 weeks collected and processed for histological sections by H/E stain. This study was done to correlate the chronological pattern of pancreas development in this geographical eastern region of India, Odisha & compare the results from other researchers nationwide & worldwide.
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